Cellular Biophysics and Modeling

Cellular Biophysics and Modeling

A Primer on the Computational Biology of Excitable Cells

Conradi Smith, Greg

Cambridge University Press






15 a 20 dias


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1. Introduction; Part I. Models and Odes: 2. Compartmental modeling; 3. Phase diagrams; 4. Ligands, receptors and rate laws; 5. Function families and characteristic times; 6. Bifurcation diagrams of scalar ODEs; Part II. Passive Membranes: 7. The Nernst equilibrium potential; 8. The current balance equation; 9. GHK theory of membrane permeation; Part III. Voltage-Gated Currents: 10. Voltage-gated ionic currents; 11. Regenerative ionic currents and bistability; 12. Voltage-clamp recording; 13. Hodgkin-Huxley model of the action potential; Part IV. Excitability and Phase Planes: 14. The Morris-Lecar model; 15. Phase plane analysis; 16. Linear stability analysis; Part V. Oscillations and Bursting: 17. Type II excitability and oscillations; 18. Type I excitability and oscillations; 19. The low-threshold calcium spike; 20. Synaptic currents.
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